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IMPAACT4HIV

On this page, explore how research drives progress in AHD care — with access to key studies, clinical trial results, guidelines, and insights shaping policy and practice across sub-Saharan Africa.

This page offers clinical resources, training tools, patient support, policy content, multimedia, and accessibility features — all designed to support comprehensive care and education.

From Evidence to Action: Using Community-Led Monitoring to Strengthen AHD Services

Country & district/site: Mozambique – Matola Provincial Hospital and Manhiça Health CentreOrganisation: MATRAMMain AHD area: CLM/Advocacy, AHD Identification, Health Systems Strengthening What Was the Problem? While many people living with HIV were receiving antiretroviral treatment, community members continued to report concerns about the quality and completeness of Advanced HIV Disease services. There was limited information […]

How Community Support Helped Raquel Take Control of Her HIV Treatment

Country & district/site: Mozambique Organisation: MATRAM Main AHD area: ART Adherence, Adolescent HIV What Was the Problem? Raquel, a 12-year-old girl living with HIV, had acquired HIV at birth and was struggling to adhere to treatment. Her mother worked long hours and was rarely at home, leaving much of Raquel’s care to a neighbour who […]

When the Activists Came Knocking

Country & district/site: Mozambique – Tsalala, Matola CityOrganisation: MATRAMMain AHD area: Paediatric AHD, Referral & Linkage, ART Adherence What Was the Problem? In the Tsalala neighbourhood of Matola City, a young mother was struggling to care for three children on her own after separating from their father. Her youngest child, six-month-old Gerson, had been born […]

Beyond the Clinic Walls – When Survival Comes Before Health

Country & Site South Africa – Khuma, Stilfontein Organisation Lefika La Ka Main AHD Area Referral & Linkage, CLM/Advocacy What Was the Problem? As part of community tracing activities, the Lefika La Ka team was working to locate individuals who had interrupted HIV treatment and were no longer attending health facilities for medication collection. The […]

When HIV Meets Poverty, Disability and Family Breakdown

Country & Site South Africa – Khuma, Stilfontein Organisation Lefika La Ka Main AHD Area Paediatric AHD, ART Adherence, CLM/Advocacy What Was the Problem? During a household tracing visit, the community team arrived at the address recorded by the health facility only to discover that the child they were searching for no longer lived there. […]

The Child Who Slipped Through the Gaps

Country & Site South Africa – Khuma, Stilfontein Organisation Lefika La Ka Main AHD Area Paediatric AHD, Referral & Linkage, ART Adherence What Was the Problem? As part of household visits to children living with HIV who were experiencing poor viral suppression, the community team set out to visit three households identified by the health […]

How Community Dialogue Helped Tuli Return to HIV Care in South Africa

Create a sidebox for the summary details:   Country: South Africa   Organisation involved: Lefika La Ka   Target population: Children living with HIV  Strategy: peer-to-peer education, household contact tracing and home vists  Partner: Lefika La Ka with support from Aurum Institute and PATA  Introduction  For many children living with HIV, the challenges they face extend far beyond the clinic. Poverty, unstable housing, and family stress can make it difficult to stay on […]

Advanced HIV disease in East Africa and Nigeria, in The African Cohort Study

Ikwo K Oboho a,✉, Allahna L Esber b,c, Nicole Dear b,c, Heather N Paulin a, Michael Iroezindu b,d, Emmanuel Bahemana b,e, Hannah Kibuuka f, John Owuoth g,h, Jonah Maswai b,i, Neha Shah b, Trevor A Crowell b,c, Julie A Ake b, Christina S Polyak b,c, AFRICOS Study Group PMCID: PMC11008437  PMID: 38427929 Supplemental Digital Content is Available in the Text. Key Words: advanced HIV disease, test and treat, CD4 testing, ART suppression Abstract Background: Earlier antiretroviral therapy (ART) may decrease progression to advanced HIV […]

Implementation of a rapid diagnostic assay package for cryptococcosis, histoplasmosis and tuberculosis in people living with HIV in Paraguay

Gloria Aguilar, Gladys Lopez, Omar Sued,  Narda Medina, Diego H. Caceres, Jose Pereira, Alexander Jordan, Virgilio Lezcano, Cristina Vicenti, Gustavo Benitez, Tania Samudio & Freddy Perez    Abstract Background Opportunistic infections (OIs) are common causes of mortality among people living with HIV (PLHIV). We determined prevalence and 30-day mortality due to histoplasmosis, cryptococcosis, and TB in PLHIV with advanced HIV disease (AHD).   […]

Understanding health systems challenges in providing Advanced HIV Disease (AHD) care in a hub and spoke model: a qualitative analysis to improve AHD care program in Malawi

Thulani Maphosa 1, Lise Denoeud-Ndam 2, Lester Kapanda 3, Sarah Khatib 4, Lloyd Chilikutali 3, Eddington Matiya 3, Boswell Munthali 3, Rosalia Dambe 3, Brown Chiwandira 5, Bilaal Wilson 5, Rose Nyirenda 5, Laywell Nyirenda 3, Bongani Chikwapulo 6, Owen Madeira Musopole 6, Appolinaire Tiam 7, Leila Katirayi 7   Affiliations Expand   Abstract Background: Despite tremendous progress in antiretroviral therapy (ART) and access to ART, many patients have advanced human immunodeficiency virus (HIV) disease (AHD). Patients on AHD, whether initiating ART or providing care after disengagement, have […]

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