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IMPAACT4HIV

On this page, explore how research drives progress in AHD care — with access to key studies, clinical trial results, guidelines, and insights shaping policy and practice across sub-Saharan Africa.

This page offers clinical resources, training tools, patient support, policy content, multimedia, and accessibility features — all designed to support comprehensive care and education.

Tracking cryptococcal meningitis to monitor HIV program success during the Treat-All era: an analysis of national data in Botswana

James Milburn 1 2, Ookeditse Ntwayagae 3, Rachita Suresh 1, Kebatshabile Ngoni 1, Cassie Northcott 1, James Penney 1, Matthew Kinsella 1, Imogen Mechie 1, Samuel Ensor 1, Goitseone Thamae 1, Tshepo Leeme 1, David S Lawrence 1 2, Tony Chebani 4, Daniel Grint 5, Mark W Tenforde 6, Ava Avalos 1, Dinah Ramaabya 4, Justus Ogando 7, Margaret Mokomane 8, Madisa Mine 9, Joseph N Jarvis 1 2 Affiliations Expand Abstract Background: Cryptococcal meningitis (CM) causes substantial mortality in African countries with a high prevalence of human immunodeficiency virus (HIV), despite advances in disease management and increasing antiretroviral therapy (ART) […]

Prevalence of advanced HIV disease and associated factors among antiretroviral therapy naïve adults enrolling in care at public health facilities in Kampala, Uganda

Bridget Ainembabazi 1, Elizabeth Katana 2, Felix Bongomin 3 4, Phillip Wanduru 5 6, Roy William Mayega 1, Aggrey David Mukose 1   Affiliations + Expand     Abstract   Background: Despite adoption of the ‘test-and-treat’ strategy, a high proportion of antiretroviral therapy (ART) naïve people living with HIV (PLHIV) enrol in care with, and die of advanced HIV disease (AHD) in Uganda. In this study, we aimed to […]

Health-Related Quality of Life in People with Advanced HIV Disease, from 1996 to 2021: Systematic Review and Meta-analysis

I Portilla-Tamarit 1 2 3 4, M Rubio-Aparicio 5 6, M J Fuster-RuizdeApodaca 7 8, J Portilla-Tamarit 2 3 4, S Reus 2 3 4 9, J Portilla 2 3 4 9   Affiliations Expand   Abstract in English, Spanish The purpose of the study was to assess the effects of advanced HIV disease (AHD) on health-related quality of life (HRQoL) in PLHIV, the changes in HRQoL outcomes over the last 25 years, and the differences between countries according to level of economic […]

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